Question of the Day

Discussion in 'General Discussion' started by Evan, Nov 29, 2017.

  1. Evan
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    Evan Donator

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    JK Rowling made an excellent puzzle. If you haven't read the book, I also left out the dialogue where Hermione comments on the size of some of the potions ~f17

    Couldn't make it too easy now could I. You're right, yours is correct for what was given, but hey, I was also curious to see who would google it and just give the answer despite the picture being gone ~f18 The take home from the book was that most witches and wizards lack logic because they live in an illogical world where magic can surpass reason. You're either a very good Wizard or a muggle who has to stick to logical reason.

    edit: the reason for the potions going forward and back by the by was because Harry needed to go forward and Hermione needed to go back and take care of Ron. Also unlike the potion shop in Kerning, I'm pretty sure the misuse of potion is bad for your health :p
     
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  2. Aly
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    Aly Magical Mermaid Princess

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    How has no one done this yet lol

    I got 8 off the bat (I think) and googled the rest, only took like 45 mins ^.^
     
  3. Sawngo
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    Sawngo Donator

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    I can't seem to find anything on 1 and 9.
    And I hate leaving answers blank... but I give up.

    1.
    2. Love Actually
    3. Elf
    4. Scrooged
    5. Die Hard
    6. Bad Santa
    7. Polar Express
    8. It's A Wonderful Life
    9.
    10. The Nightmare Before Christmas
    11. Home Alone
    12. A Christmas Story
    13. National Lampoon's Christmas Vacation
    14. How The Grinch Stole Christmas
    15. Love Actually
     
  4. Evan
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    Evan Donator

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    1 and 9 are The Santa Clause and A Christmas Carol!

    Kind of sad no one else jumped in on this one though D:
     
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  5. Evan
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    Evan Donator

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    Question #18
    Took a little break everyone but I read this one in the newspaper and had to share it. No google!

    "If I am holding a bee, what do I have in my eye?"
     
  6. Gabriel A
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    Gabriel A Donator

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    the needle of the bee? -.-'
     
  7. Kelloggs
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    Kelloggs Well-Known Member

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    Hmm, they say beauty is in the eye of the BEE-holder !
     
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  8. Evan
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    Evan Donator

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    Question #19
    Got one from @Kai today!
     
  9. FireHeart
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    FireHeart Donator

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  10. Evan
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    Evan Donator

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    Question #20
    No clue what the answer is to this.... but it sounds fun. I'm curious to see what people post for this.
    1516683235117.jpg
     
  11. Sawngo
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    Sawngo Donator

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    This one was hella fun, but lowkey hella easy. :8):

    Answer Explained:
    image1.JPG
    image2.JPG

    tl;dr:
    image3.JPG

    Q1 Answer: 20%
    Q2 Answer: 33.33% or 1/3

    P.S.: The "tricky" part here is the fact that the four cards are assorted in a deck. I mean, any other assortment (a line, a circle, etc.) would still pull the same 24 Combinations. But yeah.
     
    Last edited: Jan 23, 2018
  12. Nessi
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    Nessi Donator

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    I think you made it looks more difficult than it is , unless I missed something ?

    First question : there are 5 possibilities .

    A1,D1
    A1,D2
    A2,D1
    A2,D2
    A1,A2

    1/5 - 20%

    Second question : There are 3 possibilities .

    A1,D1
    A1,D2
    A1,A2

    1/3 - 33.333 %
     
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  13. Sawngo
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    Sawngo Donator

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    Eh, kinda, haha. I only realized that recently though. I wanted to be extra thorough, just in case I overlooked any part of the riddle.

    But yeah, essentially it wouldn't matter if As/Ac/2s/2c is in either Hole Card Position.
     
  14. Evan
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    Evan Donator

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    Question #21
    Totally stealing this one from my medchem study guide..... *cough*
    Diuretics lower your blood pressure by flushing salt out of your body, taking this unwanted extra fluid with it. There are many kinds (loop, thiazide, etc and crap). One of the most commonly prescribed is HCTZ (Hydrochlorothiazide).

    The little fella looks like this:
    Screen Shot 2018-02-05 at 8.09.51 PM.png
    But don't be fooled, the little bugger is small enough you could fit like 5 of them on your fingernail sitting side-by-side.

    Question: what makes it a "hydro"chlorothiazide and not a chlorothiazide... (the key part is the hydro part). I want details!
     
  15. Evan
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    Evan Donator

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    This one is still open people. lol.

    Nice try Succaneer.
     
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  16. Venin
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    Venin Well-Known Member

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    Hydro = water.

    You said the medicine works by 'flushing salt out of your body'. Naturally, the human body excretes salt by perspiration or urination. Since both of these are in a water medium, it suggests that the medicine only works when the body is sufficiently hydrated. So I can only guess that the 'hydro' in that name means it should be taken with plenty of water else it's not going to be effective.

    Also, I guess the reason why the medicine is so small is because small doses are ideal; any larger and it's dangerous? To maintain the safe levels of consumption, the concentration of the medicine in the body must be sufficiently low, hence also the need for drinking lots of water, supporting my point above.
     
  17. Penny
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    Based on the name, I'd say that the difference between hydrochlorothiazide and chlorothiazide would be an extra hydrogen on hydrochlorothiazide (similar to hydrochlorides and other similar salts). Hydrochlorothiazide should be chlorothiazide + a hydrogen... guessing a double bond converted into a single with the extra hydrogen put on either a carbon or a nitrogen.
     
  18. Evan
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    Evan Donator

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    ~f17
    The hydrogen at the top, if you remove it, it instead forms a double bond (because nitrogen likes to have 3 bonds).
    Screen Shot 2018-02-12 at 12.17.58 PM.png
    ^^ Hydrochlorothiazide

    And this one here...
    Screen Shot 2018-02-12 at 12.20.06 PM.png
    Is chlorothiazide
     
  19. Evan
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    Evan Donator

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    The thread is more or less on hiatus because school sucks but I thought I'd share what I'm working on tonight. :p

    1. Bisphosphonates are used extensively in conditions with osteoclast-mediated bone resorption:
    a. True
    b. False​

    2. Propylthiouracil (PTU) and methimazole (MMI) are anti-thyroid drugs. Why is PTU the drug of choice for the treatment of thyroid storm?
    a. Because MMI has a short half-life.
    b. Because PTU can block peripheral conversion of T4 and T3
    c. Because MMI is only used for preparation for thyroid surgery
    d. Because PTU has a longer duration of action.​

    3. Which of the following statements are true of pharmacologically active substrates secreted by the pancreatic islets?
    a. Alpha cells secrete insulin
    b. Insulin increases blood glucose
    c. Somatostatin stimulates insulin secretion
    d. Glucagon increases blood glucose​

    4. A newborn baby in a hospital where you work as a pharmacist has deficient thyroid function. What is the best course of therapy in this situation?
    a. Lugol’s solution during the first 2 weeks of postnatal life
    b. PTU during the first 2 weeks of postnatal life
    c. Thyroid hormone supplementation during the first 2 weeks of postnatal life
    d. MMI during the first 2 weeks of postnatal life because the PTU associate hepatic failure has been increasingly recognized, especially in children and pregnant women. ​

    5. Which of the following statements is true regarding the drug Raloxifene? (Select one)
    a. It has agonist action on estrogen receptors in uterine tissue
    b. It has agonist action on estrogen receptors in the mammary glands
    c. It is an aromatase inhibitor
    d. It has agonist action on estrogen receptors in the bones​

    6. Which of the following diabetes medications is classified as a sulfonylurea?
    a. Linagliptin
    b. Glipizide
    c. Repaglinide
    d. Sitagliptan​

    7. Which of the following are used for induction of labor
    a. Oxytocin-receptor antagonists
    b. Oxytocin
    c. COX inhibitors
    d. Calcium Channel Blockers​

    8. Why does estrogen relieve hot flashes but SERMS such as tamoxifen and raloxifene do not?
    a. Because estrogen is an agonist in all tissues while SERMS are agonists in some tissues and antagonists in others
    b. Because SERMS produce heat in response to environmental changes in temperature and diet
    c. Because estrogen is an agonist and SERMS are antagonist
    d. Because SERMS make most biological processes thermodynamically less efficient for the sake of producing heat​

    9. Which of the following statements is FALSE with regards to calcitonin?
    a. It inhibits bone resorption
    b. It acts by binding to a specific receptor on osteoclasts and inhibiting the activity of these cells
    c. It is a hormone secreted by specialized cells in the adrenal cortex
    d. It is used to treat Paget’s disease.​

    10. Which of the following statements describing the role of parathyroid hormone in bone remodeling is FALSE?
    a. The parathyroid hormone is involved in the maintenance of the plasma calcium concentration by increasing the calcium reabsorption in the renal tubules.
    b. The parathyroid hormone is involved in activation of calcitriol
    c. The parathyroid hormone is involved in the maintenance of the plasma calcium concentration by mobilizing calcium from bone.
    d. The parathyroid hormone has no effect on phosphate excretion.​

    11. The process of bone remodeling involves breakdown of bones by osteoclasts and formation of new bone matrix by osteoblasts
    a. True
    b. False​

    12. Hormone replacement therapy can be used for the prevention of which of the following conditions?
    a. Breast cancer
    b. Dementia
    c. Osteoporosis
    d. Stroke​

    13. Which, if any, of the following statements are true of the corticosteroid hormones secreted from the adrenal cortex?
    a. A deficiency of corticosteroids is the basis of Cushing’s disease
    b. An excessive production of glucocorticoids is the basis of Adison’s disease
    c. Mineralocorticoids are the main corticoids involved in the control of water and electrolyte balance
    d. Mineralocorticoids are the main corticoids involved in the control of carbohydrate and protein metabolism. ​

    14. Choose the correct statements about tamoxifen
    a. Inhibits proliferation of endometrial cells and causes endometrial thinning
    b. Stimulates the proliferation of cancer breast cells
    c. Relief of hot flashes
    d. Exhibits anti-estrogenic, estrogenic, or mixed activity.​

    15. A 40 year old female is undergoing infertility treatments. Which of the following drugs might be included in her treatment regime?
    a. Cabergoline
    b. Methimazole
    c. Vasopressin
    d. Clomiphene​

    16. One of the differences between Type 1 and Type 2 diabetes is that in Type 1, the Beta-cell destruction is so all encompassing that the patient has virtually no insulin that can be secreted from the pancreas
    a. True
    b. False​

    17. Which of the following hormone is NOT secreted by the pituitary gland?
    a. Adrenocorticotropic Hormone (ACTH)
    b. Low thyroid stimulating hormone (TSH)
    c. Vasopressin
    d. Cortisol​

    18. Which of the following is the treatment of choice for hypothyroidism?
    a. Liotrix
    b. Levothyroxine
    c. Liothyronine
    d. Iodide​

    19. At the mid of the menstrual cycle, serum _________ rises above a threshold level. This sustained elevation triggers the pre-ovulatory surge of LH and FSH. The mid cycle surge in gonadotropins stimulates follicular rupture and __________ within 1-2 days. The ruptured follicle then develops into the corpus luteum, which produces large amounts of __________ and lesser amounts of ____________. In the absence of pregnancy, the corpus luteum ceases to function, steroid levels drop, and menstruation occues.
    a. Progesterone / ovulation / FSH / LH
    b. Estradiol / ovulation / progesterone / estrogen
    c. GnRH / menses / estrogen / progesterone
    d. Progesterone / menses / FSH / LH​

    20. A 1st year pharmacy student asks you to explain the difference between glucagon and glycogen. You reply:
    a. Glucagon and glycogen are exactly the same thing.. its just that one is stored in the gallbladder, and the other is stored in the thyroid
    b. Glucagon oes not occur naturally in the human body; it must be injected. Glycogen is naturally occurring and found in bone marrow
    c. Glucagon stimulates the uptake of glucose and glycogen stores insulin
    d. Glucagon is secreted from the pancreas and prompts the liver to increase glucose production, glycogen is the storage unit of glucose.​

    21. Which of the following are used as emergency contraceptives (select all that apply)
    a. Levonorgestral
    b. Desogestrel
    c. Mifepristone
    d. Uliprestal​

    22. In the early follicular phase of the menstrual cycle (before ovulation), the pulse generator produces pulses of _________ secretion, these cause a corresponding pulsate release of __________ and __________ from pituitary gonadotropes.
    a. GnRH / Estrogen / Progresterone
    b. Cholesterol / FSH / LH
    c. GnRH / FSH / LH
    d. Cholesterol / estrogen / progesterone​

    23. Which of the following are the main hormones involved in bone turnover
    a. Mineralocorticoids
    b. Somatostatin
    c. Parathyroid Hormone
    d. Thyroxine​

    24. Which form of estrogen is secreted after menopause
    a. Estrone
    b. Estriol
    c. Estradiol​

    25. Which of the following hormones is NOT important for maintaining calciums levels in the body?
    a. Glucagon
    b. Calcitriol
    c. Calcitonin
    d. Parathyroid hormone​

    26. Metformin’s glucose lowering action is best described as
    a. Decreases gluconeogenesis of the liver and increases insulin sensitivity of the skeletal muscle
    b. Delays the gastric emptying time of carbohydrates
    c. Stimulates insulin release from the beta-cells
    d. Enhances the effect of GI incretions​

    27. Which of the following is the main hormone secreated by the thyroid gland?
    a. Parathyroid hormone
    b. Thyroxine
    c. Calcitonin
    d. Thyrotrophin​

    28. Which of the following statements about insulin is true?
    a. It increases gluconeogenesis in the liver
    b. Its overall effect is to conserve the fuel supplies in the body
    c. It’s principle effect is to increase blood glucose
    d. It increases glycogen synthesis in the liver and muscle​

    29. Which, if any, of the following hormones are secreted by the adrenal cortex? (select all that apply)
    a. Adrenaline
    b. Adrenocorticotrophic hormone (ACTH)
    c. Mineralocorticoids
    d. Glucocorticoids​

    30. DW is a patient with type 2 diabetes who has a blood glucose of 400 mg/dL today at his office visit. The physician would like to give some insulin to bring the glucose down before he leaves the office. Which of the following would lower the glucose in the quickest manner in DW.
    a. Insulin glargine
    b. NPH insulin
    c. Insulin aspart
    d. Regular insulin​

    31. Growth hormone secretion is promoted by GNRH and suppressed by _______?
    a. IGF-1
    b. Prolactin
    c. Somatostatin
    d. Statins​

    32. OP is a 65 year old female who has been diagnosed with postmenopausal osteoporosis. She has no history of fractures and no other pertinent medical conditions. Which of the following would be most appropriate for management of her osteoporosis
    a. Alendronate
    b. Raloxifene
    c. Denosumab
    d. Calcitonin​

    33. An example of an incretin (GLP-1 agonist) mimetic analog is:
    a. Exenatide
    b. Metformin
    c. Glyburide
    d. Sitagliptin​

    34. Which of the following statements is characteristic of metformin?
    a. Metformin undergoes significant metabolism via the cytochrome P450 system
    b. Metformin decreases hepatic glucose production
    c. Metformin should not be combined with sulfonylureas or insulin
    d. Metformin is inappropriate for initial management of type-2 diabetes.​

    35. In which situation below is the use of levonorgestrel appropriate?
    a. Hormone replacement therapy in women with a uterus
    b. Hormone replacement therapy in women without a uterus
    c. In case of emergency contraceptive
    d. In case of infertility due to anovulation​

    36. Incretins are another name for the hormone found in the human “gut”; they are otherwise known as glucogon-like peptide 1 (GLP-1)
    a. True
    b. False​

    37. Which of the following classes of oral diabetes drugs is paired most appropriately with its primary mechanism of action?
    a. DPP-4 Inhibitor – inhibits breakdown of complex carbohydrates
    b. Sulfonylureas – increases insulin secretion
    c. Thiazolidenedione – decreases hepatic gluconeogenesis
    d. Glinide – increases insulin sensitivity​

    38. A 53 year old woman has severe vasomotor symptoms (hot flashes) associated with menopause. She has no pertinent past medical information or surgical history. Which of the following would be most appropriate for her symptoms?
    a. Injectable medroxyprogesterone acetate
    b. Oral estradiol and medroxyprogesterone acetate
    c. Estradiol transdermal patch
    d. Conjugated estrogens vaginal cream​

    39. Serum concentrations of thyroid hormones are precisely regulated by the pituitary hormone X, in a classic negative feedback system. X secretion is precisely controlled by Y and the concentrations of Z in the circulation.
    a. X = thyrotropin (TSH) / Y = thyroglobulin / Z = thyrotropin releasing hormone (TRH)
    b. X = TRH / Y = TSH / Z = thyroid hormones
    c. X = T4 / Y = TRH / Z = Thyrotropin
    d. X = TSH / Y = TRH / Z = thyroid hormones​


    Answer Key
    1. A
    2. B
    3. D
    4. C
    5. D
    6. B
    7. B
    8. A
    9. C
    10. D
    11. A
    12. C
    13. C
    14. D
    15. D
    16. A
    17. D
    18. B
    19. B
    20. D
    21. A+D
    22. C
    23. C
    24. A
    25. A
    26. A
    27. B
    28. B
    29. C+D
    30. C
    31. C
    32. A
    33. A
    34. B
    35. C
    36. A
    37. B
    38. B
    39. D
     
  20. Moose
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    Moose Donator

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    Some of these questions from a nursing standpoint make me want to scream "the fuck you doin".
    (ie: #30, we'd never give insulin in dextrose-water (let alone) to a diabetic patient with a glucose of 400 in an office.)

    Other than that, a majority of these questions Ive had to answer on exams for previous clinical courses.
     

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