So I noticed this when using meso explosion against Krexel one time, where i did damage to the boss but the bags didn't actually blow up, so i ended up saving a lot of time, I am unsure as to how it actually works or what triggers this, and I am too lazy to do further testing, but I think it has to do something with the bags staying up for a long time or getting hit right before casting meso explosion. This happens randomly for me, sometimes for a long time but sometimes only once or twice, if I stop using meso explosion once it starts for a few seconds and then cast it again then it goes bag to normal and explodes the mesos. in the low quality picture that you can barely understand what is going on you can see that i casted meso explosion, it hit big foot and did damage to him but the bags i dropped didn't explode, which made killing the boss easier.(I took the screenshot from a recording i did to when trying to figure out how to bug works, and to catch it on camera but i still don't know why it happend)
This is a known issue and considered glitch abuse. It happens when you're to far away from the mesobags when using ME.